APPROACH TO SPLENOMEGALY

Congestive Infectious Infiltrative Inflammatory Hemolytic Disease Splenomegaly APPROACH TO SPLENOMEGALY Non-Malignant Malignant Cirrhosis Thrombus (e.g. Hepatic, Portal, Splenic) Bacterial Viral (EBV) Parasitic Fungal Systemic Lupus Erythematosus Sarcoidosis Felty's Disease Serum Sickness Sickle Cell Disease (children) Thalassemia Congenital Spherocytosis Acquired causes Amyloidosis Gaucher's Disease Glycogen Storage Disease Lymphoma Leukemia Myeloproliferative disorders (eg. polycythemia vera, essential thrombocytosis, myelofibrosis) Evidence of portal hypertension or coagulopathy? Blood smear abnormalities?