Splenomegaly
Malignant
Infiltrative Inflammatory
• Lymphoma (Hodgkin & 
Non-Hodgkin)
• Leukemia
• Myeloproliferative 
disorders (eg.
Polycythemia vera, 
essential 
thrombocytosis, 
myelofibrosis)
Hemolytic Disease
Infectious
Congestive
Non-Malignant
• Bacterial
• Viral (EBV)
• Parasitic
• Fungal
• Cirrhosis
• Thrombus (eg. Hepatic, 
Portal, Splenic)
• Systemic Lupus 
Erythematosus
• Sarcoidosis
• Felty’s Disease
• Serum Sickness
• Sickle Cell Disease 
(children)
• Thalassemia (alpha & 
beta)
• Congenital 
Spherocytosis
• Acquired causes
Blood smear 
abnormalities?
Evidence of portal 
hypertension or 
coagulopathy?
• Amyloidosis
• Gaucher’s Disease
• Glycogen Storage 
Disease