ACUTE KIDNEY INJURY

ACUTE KIDNEY INJURY Acute Kidney Injury Acute increase in creatinine by at least 50% Post-Renal (Obstruction/hydronephrosis on U/S) Pre-Renal (FeNa < 1%, bland urine sediment) Renal Hypoperfusion Systemic Hypotension Vascular (Thrombocytopenia and schistocytosis on CBC) Glomerular (RBC casts, dysmorphic RBCs) Interstitial (Sterile pyuria, eosinophiluria) Hepatorenal syndromes Drugs Emboli ShockAcute Tubular Necrosis (Epithelial cell casts) Tubular Obstruction Cast nephropathy (multiple myeloma) Urate crystals Calcium Oxalate (Ethylene glycol) Ischemia (severe hypotension) Toxins (contrast, aminoglycosides, chemotherapy) Pigments Anti-GBM antibodies Immune-complex deposition (IgA, post-strep, lupus) Pauci-immune (Wegener's)Renal(FeNa > 2%) TubularTTP/HUSRapidly Progressive Glomerulonephritis Acute Interstitial Nephritis Drugs (NSAIDs, Abx, allopurinol, PPI) Infections (CMV, strep, legionella) Immune (lupus, sarcoid, Sjgren) Shiga-like toxin (E. coli) Drugs HIV Malignancy Benign Prostatic Hyperplasia Constipation Prostate Cancer Urolithiasis Urinalysisand CBC