THROMBOCYTOPENIA

Decreased Production Increased Sequestration Increased Destruction Decreased Megakaryopoiesis Ineffective Megakaryopoiesis Immune Non-Immune Low Platelet Count • Splenomegaly •Thrombus • Marrow displacement (e.g. Leukemia*, lymphoma*, neuroblastoma*, other tumour*) • Marrow Failure (Eg. Aplastic Anemia) • Toxic Damage (e.g. Chemotherapy) • B12 Deficiency • Folate Deficiency • Drugs • Hemolytic Uremic Syndrome* • Thrombotic Thrombocytopenia Purpura • Disseminated Intravascular coagulation • Infection/sepsis* • Foreign Surface (e.g. Prosthetic Heart Valve) • Immune Thrombocytopenia Purpura* • Lupus • Alloimmune destruction • Drugs Bleeding/Bruising Approach to Thrombocytopenia Author: Adapted from Black Book Reviewer: Dr. Theresa Wu Student Reviewer: *Indicates Key Condition This is not an exhaustive list of medical conditions