MICROCYTIC ANEMIA

Microcytic Anemia Iron Deficiency* Ferritin decreased, serum iron decreased, TIBC increased Fe/TIBC <18% MCV/RBC <13 Causes: Reduced dietary intake (over consumption of cow’s milk) Malabsorption (e.g., Celiac disease, Inflammatory Bowel Disease) Chronic Blood Loss Anemia of Chronic Disease Ferritin normal/increased, serum iron decreased, TIBC normal/decreased Fe/TIBC >18% Causes: Chronic inflammation (e.g., Juvenile Idiopathic Arthritis, Inflammatory Bowel Disease, Lupus, etc.) Hemoglobinopathies* Ferritin normal/increased, serum iron normal, TIBC normal MCV/RBC <13 +/- basophilic stippling +/- increased reticulocytes Types: β-Thalassemia Minor Increased HgbA2 Normal HgbA β-Thalassemia Major Increased HgbA2 Increased HgbF No HgbA α-Thalassemia 2–3 gene deletion Increased HgbH HgbH inclusions in RBC *Indicates Key Condition This is not an exhaustive list of medical conditions.