Urine Osmolality < Serum Osmolality Increased Urinary Frequency Urinary Tract Infection Other Urinary obstruction (Eg. Nephrolithiasis) Small volume bladder Detrusor hyperactivity Vulvovaginitis* Bladder compression Constipation* Mass Pregnancy Genitourinary Complaints: Clinical approach to increased urinary frequency *Indicates Key Condition This is not an exhaustive list of medical conditions. See “Genitourinary Complaints: Clinical approach to Dysuria” Detailed history and physical exam No polyuria u/o>7mL/kg/hr, or inappropriately high for intake Urinalysis Urine Culture Urine culture positive Urine culture negative u/o<7mL/kg/hr, and u/o appropriate for intake Polyuria Osmotic Diuresis Water Diuresis Hypotonic urine Hypertonic Urine Central Diabetes Insipidus Nephrogenic Diabetes Insipidus Diabetes Mellitus* Renal Failure * (high output) Iatrogenic (Mannitol, NaCl) Check serum and urine osmolality Urine Osmolality > Serum Osmolality Water deprivation test Diabetes Insipidus Primary polydipsia

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