GLOBAL DEVELOPMENTAL DELAY/INTELLECTUAL DISABILITY

Global Developmental Delay/ Intellectual Disability Delays in 2 or more domains including Motor (fine and/or gross motor) Language Social Detailed medical and developmental history Physical Examination Developmental Observations Consider social/environmental impacts Prenatal Intrinsic Genetic (Eg. Trisomy 21*, Fragile X, Rett syndrome, 22q11 deletion) Metabolic disease* CNS malformations Congenital hypothyroidism Extrinsic Teratogens/Toxins (Eg. alcohol, drugs, medications) Congenital infections* (Eg. TORCH infections) Perinatal Prematurity* Birth trauma* (Eg. intracranial hemorrhage, asphyxia/Hypoxic ischemic encephalopathy) Neonatal complications Postnatal Trauma and brain injury (hypoxia, abusive head trauma*, accidental trauma, etc.) CNS infection (Eg. Meningitis*, encephalitis*) Neglect* Toxins (Eg. lead) *Indicates Key Condition This is not an exhaustive list of medical conditions.