Global Developmental Delay / Intellectual Disability Delays in 2 or more domains including: Motor (fine and/or gross motor) Language Social Developmental Observations Consider social/environmental impacts Prenatal Intrinsic Genetic (e.g., Trisomy 21*, Fragile X, Rett syndrome, 22q11 deletion) Metabolic disease* CNS malformations Congenital hypothyroidism Extrinsic Teratogens/Toxins (e.g., alcohol, drugs, medications) Congenital infections* (e.g., TORCH infections) Perinatal Prematurity* Birth trauma* (e.g., intracranial hemorrhage, asphyxia/Hypoxic ischemic encephalopathy) Neonatal complications Postnatal Trauma and brain injury (hypoxia, abusive head trauma*, accidental trauma, etc.) CNS infection (e.g., Meningitis, encephalitis**) Neglect* Toxins (e.g., lead) *Indicates Key Condition This is not an exhaustive list of medical conditions.

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