Fever: Age > 3-month Detailed History and Physical Exam Clinical features and investigations not suggestive of infection Often acute onset Infectious Bacterial Pneumonia* Otitis Media* Urinary Tract Infection* Occult bacteremia/sepsis* Meningitis*/Meningococcemia* Skin and soft tissue infections (Osteomyelitis*, septic arthritis*) Bacterial respiratory tract infections (Pharyngitis*, pertussis*, tracheitis*, pertonsillar abscess*, retropharyngeal abcess/cellulitis*, cervical adenitis*) Viral Respiratory viruses (Eg. Influenza, RSV, rhinovirus, enterovirus, adenovirus, etc.) Mononucleosis* Gastroenteritis * Other Extremely rare. Seen mostly in immunodeficiency, or occasionally acquired while traveling Fungal Protozoa (eg. malaria) other parasites Clinical features and investigations not suggestive of infection Often fever > 5 days Non-infectious Malignancy Leukemia* Lymphoma* Neuroblastoma* Brain tumor* bone tumor* Autoimmune/Inflammatory Kawasaki disease* Inflammatory Bowel Disease* Systemic Lupus Erythematous Juvenile Idiopathic Arthritis Acute abdomen* (Eg. appendicitis*)

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