ANEMIA BY MECHANISM

Anemia By Mechanism Detailed history and physical exam Normcytic normochromic RBCs increases reticulocytes If chronic may have: decreased reticulocytes MCV, MCH, MCHC, Serum iron, ferritin, increased TIBC, hypochromic RBCs Blood loss Acute bleed chronic bleed, normocytic normochromic RBCs Normal/Decreased Reticulocytes may have other cell lines down decreased RBC production iron deficiency leukemia B12/folate deficiency aplastic anemia anemia of chronic disease increased reticulocytes increased unconjugated billirubin decreased haptoglobin increased LDH spherocytes on smear hemolysis increased rbc destruction congenial hemoglobinopathies thalassemia rbc membrane disorder rbc metabolism disorder acquired immune non-immune normocytic normochromic RBCs increased reticulocytes consumption/sequestration hypersplenism splenomegaly thrombus