THROMBOCYTOSIS

Increased Sequestration Decreased Production Increased Destruction Decreased Megakaryopoiesis Ineffective Megakaryopoiesis Immune Non-Immune Autoimmune Alloimmune Drugs THROMBOCYTOPENIA Low Platelet Count Splenomegaly Aplastic Anemia Toxic Damage (e.g. Chemotherapy) Displacement (e.g. Leukemia, Tumour) B12 Deficiency Folate Deficiency Folate Antagonist (methotrexate) Drugs HELLP Syndrome TTP/HUS DIC Vasculitis Infection Foreign Surface (e.g. Prosthetic Heart Valve) ITP SLE CLL anti-HLA antibodies Quinidine Others 59