Hemolysis Extravascular Speen and RES-mediated Hemolysis Intravascular Hemolysis within circulation Extrinsic to RBC Immune Mediated Warm AIHA Cold AIHA Alloimmune delayed HTR Drug induced AIHA Intrinsic to RBC Abnornal HGB & HGB Defects Membrane Defects Hereditary spherocytosis Hereditary elliptocytosis RBC Enzyme Defects G6PD Deficiency PK Deficiency Infections Complement-Medicated Cold AIHA PCH PNH Drug-induced immune complex hemolytic anemia Acute HTR Mechanical Shearing MAHA (TTP, DIC, HUS) Prosthetic heart valves Atrovenous malformations

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