APPROACH TO PROLONGED PT (INR), PROLONGED PTT

APPROACH TO PROLONGED PT (INR), PROLONGED PTT Factor Deficiency Inhibitor Long PT (INR), Long PTT Heparin Factor X Factor V Factor II Fibrinogen Congenital Acquired Drugs Autoantibodies to a Clotting Factor in the Common Pathway (Rare) Disseminated Intravascular Coagulation Vitamin K Problem Liver Disease Antagonist Vit K Deficiency (decreases levels of Factors II, VII, IX, X, and Protein C+S) Coumadin Notes: PT more sensitive to Vitamin K deficiency; therefore DPT used for monitoring Coumadin therapy (PTT only affected in very severe cases) PTT more sensitive to heparin; therefore PTT used Dfor monitoring heparin therapy (PT only affected in very severe cases)