ABNORMAL LIPID PROFILE: Increased LDL & Increased Triglycerides Abnormal Serum Lipid Profile Increased LDL Decreased HDL Genetic Causes Secondary Causes Genetic Causes Secondary Causes Polygenic Hypercholesterolemia Familial Hypercholesterolemia Familial Defective ApoB-100LD Lr deficiency Hypothyroid Obstructive Liver Disease Nephrotic SyndromeFamilial Hypertriglyceridemia Familial LPL Deficiency Apo-CII Deficiency Diabetes Alcohol Increased Estrogen (e.g. Pregnancy, Hormone Replacement Therapy, Oral Contraceptive) Increased TriglyceridesIncreased Cholesterol and Triglycerides Physical signs: Hypertriglyceridemia: eruptive xanthoma, lipemia retinalisIncreased IDL: palmar crease xanthoma, tuberous xanthoma Increased LDL: tendon xanthomata on Achilles tendon, knuckles

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