Anemia with Low Mean Corpuscular Volume

Ferritin

normal/increased, serum

iron decreased, TIBC

normal/decreased

Fe/TIBC>18%

Ferritin decreased,

serum iron decreased,

TIBC increased

Fe/TIBC <18%

MCV/RBC>13

Ferritin

normal/increased, Serum

iron normal, TIBC Normal

MCV/RBC<13,

+/- basophilic stippling,

+/- increased reticulocytes

Increased HgbH,

HgbH inclusions in RBC

Increased HgbA2

Increased HgbF

No HgbA

Other

Decreased Heme Synthesis or Decreased Globin Synthesis

Increased HgbA2

Normal HgbA

• Iron Deficiency (Eg Causes:

Chronic Blood Loss, Occult

Bleed, Malabsorption, Dietary

Deficiency

• Anemia Secondary to

Inflammation

• B-Thalassemia Minor

• B-Thalassemia Major • Alpha-Thalassemia 2-3

digene deletion

• E.g. HgbE, HgbC, etc.