Diffuse Lymphadenopathy
Reed-Sternberg 
Cells on Biopsy
Monoclonal 
Lymphocytes on 
Biopsy
Neoplastic
• Acute Lymphoblastic 
Leukemia 
(Pancytopenia)
History of Bleeding, 
Infection, Fatigue
Reactive
Systemic 
Inflammatory
Leukemia
• EBV
• CMV
• HIV
• Tuberculosis
• Hepatitis
• Systemic Lupus 
Erythematosus
• Sarcoidosis
• Rheumatoid 
Arthritis
• Pseudotumor
• Non-Hodgkin’s 
Lymphoma
• Hodgkin’s 
Lymphoma
• Acne
• Allergy
• Insect Bites
• Young age
Infectious Other
Asymptomatic, 
Age > 50
• Chronic Lymphocytic 
Leukemia (CBC with 
Lymphocytes)